A General Method for the Synthesis of Enantiomerically Pure â-Substituted, â-Amino Acids through r-Substituted Succinic Acid Derivatives
نویسندگان
چکیده
A general procedure for the synthesis of enantiopure â-substituted, â-amino acids is presented. Alkylation of the sodium enolates derived from chiral N-acyloxazolidinone imides 2 (R ) Me, i-Pr, t-Bu, Ph, Bn) with tert-butyl bromoacetate afforded the 2-substituted succinate derivatives 3 in good yields (82-89%) and with high selectivity (g93:7). Following hydrolysis, Curtius rearrangement of the resulting carboxylic acid provided the enantiopure benzyloxycarbonyl (Cbz)-protected â-amino esters 6 in good yields (74-79%).
منابع مشابه
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